Presence of autoantibodies in sera of patients with sporadic idiopathic hypoparathyroidism
- VernacularTitle:散发性特发甲状旁腺机能减退患者体内存在自身抗体
- Author:
Shu-Guang PANG
;
Zi-Dong LIU
;
Ling GAO
;
Bin ZHU
;
Yu-Lian JIAO
;
Ying SUN
;
Chun-Yan MA
;
Bin CUI
;
Jia-Jun ZHAO
- Publication Type:Journal Article
- Keywords:
Autoimmunity;
Hypoparathyroidism;
Anti-parathyroid antibody
- From:
Chinese Journal of Laboratory Medicine
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether autoreactive antibody presents in patients with sporadic idiopathic hypoparathyroidism(sIHP).Methods The subjects including 26 patients with sIHP and 112 genealogical members as well as 60 age-and sex-matched healthy controls.Anti-parathyroid antibodies in the sera were assayed by indirect immunofluorescence.The levels of calcium,phosphorus and magnesium as well as intact parathyroid hormone(iPTH)in the sera were tested.Results Positive autoantibodies against parathyroid tissue were demonstrated in 10 patients(38%)with sIHP,significantly higher than that of in genealogical members(10%,?~2=13.42,P
