Current Research Status and Application Prospect on Transcription Factor NF-?B
- VernacularTitle:转录因子NF-?B的研究现状及其应用前景
- Author:
Yan-Hui SHI
;
Sheng-Dong LU
;
- Publication Type:Journal Article
- Keywords:
NF-?B Transcription factor Current research status Application prospect
- From:
China Biotechnology
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
NF-?B, a group of important transcription factors, are introduced and discussed here on several aspects: their component and molecular structure; their activity control by I?B and IKK, the mechanism of their activation; their important roles in transcriptional regulation for large numbers of genes; and their importance in immunity, inflammation, cell survival, proliferation and apoptosis. The analysis of the relation between NF-?B and disease occurrence, the analysis of the relation between NF-?B and disease therapy, and the application prospect of the new strategy regarding the novel drug design and correlative diseases therapy on the basis of NF-?B as the target, are also included.
