High Selective Synthesis of 11?-hydroxycanrenone by Biotransformation
- VernacularTitle:11?-羟坎利酮的高特异性生物转化合成
- Author:
Rong-Sheng TAO
;
Hai-Feng HU
;
Xiao-Dun LI
;
Bao-Quan ZHU
;
- Publication Type:Journal Article
- Keywords:
Canrenone,11?-hydroxycanrenone,Microbial transformation
- From:
Microbiology
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Canrenone is an important intermediate for the synthesis of eplerenone,a cardiovascular drug.C_ 11 ?-hydroxylation of canrenone is the key reaction,which can be done by microbial transformation.Rhizopus sp.SIPI-0602,kept in our lab,could high selectively transform canrenone to a compound named SIPI-11.By determining and analyzing the MS,UV,NMR etc.spectra of compound SIPI-11,its chemical structure was elucidated to be 11?-hydroxycanrenone.The study on flask transformation technology showed that the transformation ratio exceeded 90% when the substrate concentration was not more than 6g/L.
