Investigation of PML-RAR? fusion gene in acute promyelocytic leukemia by real-time quantitative reverse transcription PCR
- VernacularTitle:实时荧光定量PCR检测PML-RAR?融合基因的临床应用研究
- Author:
Hong YUAN
;
Nan WANG
;
Shi-Jun LI
;
Jing WANG
;
Hong ZHU
;
Xiao-Guang XIAO
;
Min HUANG
;
- Publication Type:Journal Article
- Keywords:
Gene;
Polymerase chain reaction;
Leukemia,promyelocytic,acute
- From:
Chinese Journal of Laboratory Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relapse risk assessment for patients with acute promyelocytic leukemia(APL)through testing PML-RAR? fusion gene by real-time quantitative polymerase chain reaction(RQ-PCR).Methods Relative copies of PML-RAR? fusion gene were measured in 25 patients with APL in phases of first diagnosis,complete remission(CR)and relapse.The minimal residual disease(MRD)situations were also monitored in 6 of the 25 patients.Results Different PML-RAR? fusion gene expression levels were observed in patient groups of different phases of the disease.(P
