Reference methods and reference measurement principles in clinical biochemistry
- VernacularTitle:临床生化检验参考方法及其主要分析原理
- Author:
Wen-Xiang CHEN
;
Zi-Yu SHEN
;
Zhen-Hua YANG
;
- Publication Type:Journal Article
- Keywords:
Reference method;
Isotope dilution mass spectrometry
- From:
Chinese Journal of Laboratory Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Characteristics and measurement principles of reference methods in clinical biochemistry were described.Implementation of reference systems is one of the most effective approaches to improve the accuracy and comparability of clinical laboratory test results.Reference methods are the key components of reference systems.Reference methods should have measurement uncertainties that meet the requirements of the intended use,and thus should be based on reliable measurement principles.For the well-defined biochemistry analytes,reference methods have been almost all based on instrumental analysis.Isotope dilution mass spectrometry (ID/MS) is considered most reliable and has been the major analytical principle of the reference methods.ID/MS analysis is accurate but expensive.Use of other validated instrumental analyses as reference measurement principles would be justified.
