Study on the fourth generation HIV antigen and antibody combination assays reducing the HIV diagnostic window period
- VernacularTitle:第四代HIV抗原抗体酶联检测试剂缩短HIV检测窗口期的研究
- Author:
Wen-Yan XU
;
Mao-Feng QIU
;
Tuerdi ZUOHELA
;
Wen-Ge XING
;
Yan JIANG
;
- Publication Type:Journal Article
- Keywords:
HIV;
Reagent kits,diagnosis;
Window period
- From:
Chinese Journal of Laboratory Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the ability of the fourth and the third generation HIV assay kits available in Chinese market to detect early HIV infection.Methods 8 BBI HIV seroconversion panels (PRB924,930,940,942,943,944,946 and 948) and 2 National AIDS Reference Lab's HIV seroconversion panels (2004XJ727 and 20505217) were respectively detected with one HIV antigen assay kit,2 fourth generation HIV assay kits and 4 third generation HIV assay kits.The ability of these kits to detect early HIV infection was analyzed and compared.Results For every panel,the fourth generation HIV assay kits could detect HIV-1 infection 4 to 8 days earlier than the third generation kits,and 2 to 4 days later than the antigen kit.The detection ability of different brands of kits was different.Conclusions The fourth generation HIV assay kits could reduce the window period to detect HIV infection.It's meaningful for diagnosing early HIV infection,blood safety and etc.
