The serum proteomic analysis of the adefovir dipivoxil response in the chronic hepatitis B patients
- VernacularTitle:阿德福韦酯治疗慢性乙型肝炎患者前后蛋白质组学的比较分析
- Author:
Fang GUO
;
Jiang-Hua WANG
;
Hui-Ying RAO
;
Song-Xia WANG
;
Wen-Li GUAN
;
Yan SUN
;
Hao WANG
;
Lai WEI
;
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Proteomics;
Electrophoresis,gel,two-dimensional
- From:
Chinese Journal of Laboratory Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the difference of the protein about the patient of hepatitis B who received adefovir dipivoxil(ADV)therapy,and seek the useful biomarker of effective therapy.Methods We used the two-dimensional gel electrophoresis technology to examine HBV infected serum samples aiming at searching protein's alteration after ADV therapy.Results After 1 year's treatment,haptoglobin, haptoglobin 2-alpha raised and alpha-l-antitrypsin precursor,Factor B,Chain B,transthyretin,glutathione peroxidase,alpha-2-HS-glycoprotein,retina]binding protein,retinol-binding protein precursor, apolipoprotein,apolipoprotein A-I precursor fell in viral response patients.Transthyretin raised and leucine- rich alpha-2-glyeoprotein,haptoglobin,alpha-2-actin,apolipoprotein A-I precursor fell in none viral response patients.To compare two groups:apolipoprotein A-I have the same change and haptoglobin, transthyretin have the opposite change.Conclusion Proteomics study can find the alteration of protein during the ADV treatment,and is helpful to searching the predictable biomarker to ADV.
