Risk Factors and Drug Resistance of Nosocomial Pneumonia Caused by Imipenem-resistant Acinetobacter baumannii
- VernacularTitle:耐亚胺培南鲍氏不动杆菌医院获得性肺部感染危险因素及耐药性分析
- Author:
Jia-Xi FENG
;
Yun LIN
;
Dong-Qing LV
;
- Publication Type:Journal Article
- Keywords:
Acinetobacter;
Drug-resistance;
Imipenem;
Risk factor
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the risk factors for nosocomial pneumonia(NP) caused by imipenem-resistant Acinetobacter baumannii(IRAB) and its antimicrobial susceptibility in vitro. METHODS The data of 34 cases of IRAB-NP were analyzed and 68 cases of NP caused by imipenem-susceptible A.baumannii(ISAB) were randomized as control.Antimicrobial susceptibility(MIC) was determined with the method of agar dilution. RESULTS The two independent factors associated with the development of IRAB-NP: previous fluoroquinolone(OR=5.738) and imipenem/meropenem(OR=7.129) use.The drug sensitivity test in vitro showed that these strains were multiresistant to commonly used antibiotics,and only ampicillin/sulbactam and cefoperazone/sulbactam whose resistance rate was less than 30%. CONCLUSIONS Previous imipenem/meropenem and fluoroquinolone use is independent risk factors for IRAB-NP.These strains are high drug resistant.
