CD4~+ CD25~+Regulatory T Cells、IL-2 and Immune Tolerance
- VernacularTitle:CD4~+ CD25~+调节性T细胞、IL-2与免疫耐受
- Author:
Yan-Yan QU
;
Yong ZHAO
;
- Publication Type:Journal Article
- Keywords:
Regulatory T cells IL-2 Immune tolerance
- From:
China Biotechnology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
More and more research proved that CD4+CD25+ regulatory T cells (Treg cells) play an important role in immune tolerance in these years. Known as a T cell growth factor, Interleukin2 (IL-2) regulated the immune tolerance induced by Treg cells. IL-2 sustained the activity of Treg cells both in thymus and periphery while it was dispensable for the development of Treg cells in thymus. In addition, IL-2 signal affected the function of Treg cells and maintained their competitive fitness. Therefore, CD4+CD25+ Treg cells and IL-2 formed an immune network to regulate the processes of immune response, immune tolerance and autoimmune homeostasis.
