Advances of Lentiviral Vectors Design and Application
- VernacularTitle:慢病毒载体的设计及应用进展
- Author:
Shu-Yan WANG
;
Yu ZHANG
;
- Publication Type:Journal Article
- Keywords:
Lentiviral vectors Gene therapy Transcriptional regulation Tet-on/off system
- From:
China Biotechnology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
As an efficient gene transfer vehicle lentiviral vector has been widely used in therapy research. Comparing with other retrovirus vectors, lentiviral vectors have the unique ablility of transfecting nondividing cells and terminal differentiated cells. In addition, lentiviral vectors can accommodate two or more promoters and can carry larger foreign gene insertions. Now the new generation of lentiviral vectors encoding transcriptional control sequence provides effective means for the regulation of foreign gene expression. The development of lentiviral vectors and its application in the gene therapy field were summarized.
