Progresses in the Studies of Structure-activity Correlation and Detection Methods of Medicinal Fungal ?-(1,3)-D-glucans
- VernacularTitle:药用真菌?-(1,3)-D-葡聚糖构效关系及检测方法研究进展
- Author:
Chun-Feng CHEN
;
Xiao-Tong YANG
;
- Publication Type:Journal Article
- Keywords:
?-(1,3)-D-glucan, Structure-activity correlation, Detection
- From:
Microbiology
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
?-(1,3)-D-glucan is a core structure of many bioactive fungal polysaccharides. It has drawn intensive attentions in recent because of its multiple bioactivities, particularly the immunomodulatory and antitumorous actions. In this review, we introduced the studies of structure-activity correlation of these ?-(1,3)-D-glucans, particularly the contributions of main backbone, branch degree and residues, molecular weight and conformation to the activities. We also summarized the recent progress in the detective methods for both quantitation and qualification using limulus G factor assay,galactosyl ceramide ELISA and etc.
