The Influence of Peptidoglycan of Lactobacillus on Immune Function of Mouse
- VernacularTitle:乳酸杆菌肽聚糖对小鼠机体免疫功能的调节作用
- Author:
Guang-Wei SU
;
Jin SUN
;
Yong-Hui SHI
;
Guo-Wei LE
;
- Publication Type:Journal Article
- Keywords:
Peptidoglycan Genechip Immune gene TLR-NF-?B signal pathway
- From:
China Biotechnology
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Mice was stimulated by peptidoglycan from Lactobacillus sp and detect cytokines production。It was found that PG induced the production of inflammatory cytokines (IL-1,TNF-? in peritoneal macrophages,IFN-? in spleen cell)and did not induce the IL-2 production in spleen cell. Affymetrix MOE430A genechip was used to analyze changed gene expression of immune cells. It was found that expression of cytokines and related genes were changed under peptidoglycan administration. This might induced by activation of TLR-NF-?B signal pathway.