Study on Cytotoxic Activity and Chemical Constitunents of Marine Actinomycets Strain 124092
- VernacularTitle:海洋放线菌124092细胞毒活性和化学成分研究
- Author:
Xiu-Chao XIE
;
Wen-Li MEI
;
Ling ZHUANG
;
Hai-Peng LIN
;
Kui HONG
;
Hao-Fu DAI
;
- Publication Type:Journal Article
- Keywords:
Marine actinomycetes, Cytotoxic activity, GC/MS, Chemical constituents
- From:
Microbiology
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The hexane extract from marine actinomycetes 124092 showed potent inhibition on B16 cell line by MTT assay. The hexane extract was fractionationed on silica gel column by vacuum liquid chromatography to afford 6 fractions(Fr1~Fr6), and Fr6 showed cytotoxic activity. To determine the bioacitve components of hexane extract, Fr6 was analyzed by GC/MS. The main components were identified as palmitic acid (11.76%), oleic acid (12.16%), linoleic acid (14.77%), and lactobacillic acid (61.31%). It have been reported that palmitic acid, oleic acid, and linoleic acid possess cytotoxic activity on rat ascites tumor cells and linoleic acid have suppressive effect on human lung adenocarcinoma cells.
