Distribution and susceptibility of pathogens isolated from postoperative infections in liver transplantation recipients
- VernacularTitle:肝移植患者术后感染病原菌的分布和耐药性分析
- Author:
Xiao-Jing GUO
;
Hong FAN
;
Xiao-Bo MA
;
Mei KANG
;
Jun JIAN
;
Hui-Li CHEN
;
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Pathogen;
Antibiotic;
Resistance
- From:
Chinese Journal of Infection and Chemotherapy
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the epidemiology of bacterial infections after liver transplantation and anaIyze the antimi- crobial susceptibility of major pathogens to provide reference for clinical therapy.Methods A retrospective survey was conduc ted in 174 patients who underwent liver transplantation during 2001 and 2004.Identification and susceptibility of pathogens were assayed by Microscan Walkaway 40 Automatic System.Results Infection was identified in 59.8% of the 174 patients after liver transplantation.A total of 218 non-duplicate strains were isolated.Most infections were caused by single pathogen.The infection was frequently identified in respiratory tract,biliary tract,blood stream or intra-abdominal cavity.The top 5 patho- gens were Acinetobacter baumannii,Staphylococcus aureus,Pseudomonas aeruginosa,Stenotrophomonas maltophilia and Escherichia coli.Gram-negative bacilli were usually resistant to multiple antimicrobial agents,but less resistant to piperacillin- tazobactam or imipenem.Most of S.aureus isolates were methicillin-resistant,which were susceptible to vancomyein.Conclu- sions Pathogens of postoperative infections in liver transplantation recipients are mostly multi-drug resistant.The microbiologi- cal surveillance is important for guiding clinical therapy.
