Effects of nerve growth factor on treatment of peripheral nerve injuries
- VernacularTitle:神经生长因子治疗周围神经损伤的前瞻性研究
- Author:
Yan-Tao CHEN
;
Qing HE
;
Shang-Li LIU
;
- Publication Type:Journal Article
- Keywords:
Nerve growth factor(NGF);
Peripheral nerve;
Injury
- From:
Chinese Journal of Orthopaedic Trauma
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of nerve growth factor (NGF) on the early treatment of pe- ripheral nerve injuries.Methods From April 2004 to October 2005,48 cases with peripheral nerve injury were randomly divided into therapeutic and control groups which were treated with NGF and Vitamin B12 for four weeks respectively.The changes in pain,numbness as well as neurophysiology in the two groups were assessed and compared. Results Compared with the control group,symptoms of pain and numbness in the therapeutic group were significantly alleviated (P＜0.05),the number of regenerative nerves was greater (P＜0.01),latent periods for the recovered sensory and motorial potentials of the regenerative nerves shorter,amplitudes significantly higher (P＜0.05 ),and side effects fewer.Conclusion NGF is safe and effective for early treatment of peripheral nerve injuries.
