Current development of scaffold design and fabrication in bone tissue engineering
- VernacularTitle:骨组织工程支架材料合成技术的进展
- Author:
Ji LI
;
Yu-Min ZHANG
;
Zhi-Qiang WANG
;
- Publication Type:Journal Article
- Keywords:
Bone tissue engineering;
Scaffold;
Biomaterial;
Polymeric material;
Fabrication technique
- From:
Chinese Journal of Orthopaedic Trauma
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
With the development of tissue engineering,the bone tissue engineering is developing rapidly. Engineering hone typically uses an artificial extracellular matrix (scaffold),osteoblasts or progenitors,and os- teoinductive factors which promote cell attachment,differentiation,and mineralized bone formation.Highly porous scaffolds play a critical role in cell seeding,proliferation,and new 3D-tissue formation.A variety of biodegradable polymer materials and scaffolding fabrication techniques for engineering bone have been developed over the past decade.This article reviews the scaffold design and fabrication methods tor engineering bone to analyze their ad- vantages and limitations.Various architectural parameters of scaffolds important for bone tissue engineering (e.g. porosity,pore size,interconnectivity) are discussed.
