Natural Anti-infectious Molecule:Bactericidal/permeability- increasing Protein
- VernacularTitle:天然抗感染分子-细菌透性增加蛋白
- Author:
Hai-Rong MA
;
Yi SUN
;
Xu CAO
;
Han-Qing WANG
;
- Publication Type:Journal Article
- Keywords:
Bactericidal/permeability-increasing protein Endotoxin Immunity Sepsis Lipopolysaccharide
- From:
China Biotechnology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Endotoxins are lipopolysaccharides ( LPS) , major component of out wall in Gram-negative bacteria. Often they are considered as "prime criminals" of triggering systemic inflaming reaction such as sepsis, bacteremia and so on. It was found in recent years that bactericidal/permeability-increasing protein, a 55kDa member of lipid-related protein family, was a kind of natural molecule of anti-infection and it has special endotoxin-neutralising activity and antibacterial activity. Comprehensive phase II/III clinical trials demonstrated the feasibility and safety of recombinant BPI. So pharmaceutical corporations are attracted to try to apply it to therapy.
