Prediction of Secondary Structure and B Cell Epitope for Capsid Protein of SVDV
- VernacularTitle:猪水疱病病毒外壳蛋白的二级结构和抗原表位预测
- Author:
Shi-Qi SUN
;
Xiang-Tao LIU
;
Hui-Chen GUO
;
Shuang-Hui YIN
;
Zai-Xin LIU
;
Jun-Wu MA
;
Qing-Ge XIE
;
- Publication Type:Journal Article
- Keywords:
SVDV Capsid protein Secondary structure B cell epitopes
- From:
China Biotechnology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The secondary structure of Capsid protein was predicted by the methods of Chou-Fasman,Garnier-Robson and Karplus-Schultz based on the sepuence of capsid protein gene of Swine Vesicular Disease Virus (SVDV) and hydrophilicity. Surface probility plot and antigenic index for capsid protein were obtained by the methods of Kyte-Doolittle, Emini and Jameson-wolf, respectively, Combining the results according to these methods, the B cell epitopes for capsid protein of SVDV were predicted. The results showed that there are much flexible region such as coil region and turn region in capsid protein of SVDV, there are more predominant B cell epitopes in VP1 than in VP2 and VP3. This study would be helpful for identification of B cell epitopes for capsid protein using experimental methods and research of reverse vaccine of SVDV.
