Advances in the Research of Long Life Recombinant Protein Drug
- VernacularTitle:长效重组蛋白药物的研究进展
- Author:
Nan QI
;
Qing-Jun MA
;
- Publication Type:Journal Article
- Keywords:
Long life recombinant protein drug Half life Molecule weight Drug balance Immunogenicity Analog PEGlyation Albumin fusion
- From:
China Biotechnology
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The recombinant protein drug usually has a short half-life after intravenous (IV) or subcutaneous (SC) administration. The methods of prolonging the half-life of recombinant protein drug in common use are mainly based on three principles: 1 Amplifying the molecule weight of protein drug; 2 Making use of drug balance in the blood; 3 Reducing Immunogenicity. Three methods were focused on: Analog construction, PEGylation and Albumin fusion technology. The characteristics, half-life and immunogenicity problem of their products in the market and under development are summarized.
