Microarray DNA Chip in Analyzing the Association Between HLA,DRB and Advanced Hepatosplenic Schistosomiasis
- VernacularTitle:应用基因芯片分析HLA-DRB与晚期肝脾型日本血吸虫病的相关性
- Author:
Yuli CHENG
;
Mingxing XU
;
Wenjian SONG
;
Yan YANG
;
Wenqi LIU
;
LI YONGLONG
;
Minyan QIU
;
Hai WU
;
- Publication Type:Journal Article
- Keywords:
Hepatosplenic schistosomiasis;
HLA,DRB;
DNA chip
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore possible associations between host polymorphism of HLA classⅡgenotypes and advanced hepatosplenic schistosomiasis japonica.Methods 45 advanced schistosomiasis patients(experimental group) and 44 age,and sex,matched patients with chronic schistosomiasis(control group) from the same area were investigated for their HLA class II gene DRB genotypes by genotyping the alleles using microarray DNA chip.The correlation of allele frequencies to advanced hepatosplenic schistosomiasis was compared for the two groups.Results HLA,DRB1*04x exhibited markedly higher frequency in advanced patients than that in control group(P
