Effect of Mirtazapine in Patients with Anorexia Nervosa
- VernacularTitle:米氮平治疗神经性厌食症的疗效对照研究
- Author:
Yu-Long CHEN
;
Xia WANG
;
- Publication Type:Journal Article
- Keywords:
anorexianervosa;
mirtazapine;
selective serotonin reuptake inhibitor(SSRIs)
- From:
Chinese Mental Health Journal
2002;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of mirtazapine in patients with anorexia nervosa.Methods: A randomized,controlled study was undertaken in 42 patients with anorexia nervosa.Subjects were treated with mir- tazapine or selective serotonin reuptake inhibitor(SSRIs)for 12 weeks and followed up to 12 weeks.The clinical out- come measures included body weight,Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)and the side effects of medications.Results:38 subjects completed the trial,20 in mirtazapine group,18 in SSRIs group. The weight gain in mirtazapine group was significantly more that that in SSRIs group at week 6 but the difference was not significant at week 12.The scores of HAMD and HAMA at endpoint were significantly lower than those at base- line(P0.05).No severe adverse events were observed in both groups.Common side effects of SSRIs were gastroenterological discomfort,while those of mir- tazapine included somnolence and weight gain.Conclusion:Mirtazapine can improve appetite and weight gain in pa- tients with anorexia nervosa in addition to relieve anxiety and depression.It is well tolerated and has ealier onset of effect than SSRIS.
