Effect of Paroxetine on Patients with Diarrhea-predominant Irritable Bowel Syndrome
- VernacularTitle:帕罗西汀对腹泻型肠易激综合症的疗效观察
- Author:
Yu-Long CHEN
;
Xia WANG
;
- Publication Type:Journal Article
- Keywords:
diarrhea-predominant;
irritable bowel syndrome(IBS);
paroxetine;
serotonin
- From:
Chinese Mental Health Journal
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate efficacy of paroxetine in the treatment of diarrhea-predominant irritable bowel syndrome(D-IBS).Methods:In a self-controlled trial,45 patients with D-IBS symptoms according to the Rome Ⅱ criteria were treated with paroxetine 10mg Qd for 12 weeks.The efficacy measures included D-IBS gastroin- testinal symptoms,abnormal frequency or consistency of defecation,Hamilton Depression Scale(HAMD)and Hamil- ton Anxiety Scale(HAMA).Results:42 cases completed 12 week therapy.The overall IBS symptoms,the Bristol stool consistency,stool frequency and abdominal pain were relieved significantly at week 2(P
