Effects of Hydergine on expression of N-methyl-D-aspartate receptors in hippocampus and actions of mice with ischemia-reperfusion injury
- VernacularTitle:喜得镇对脑缺血再灌注小鼠的行为及海马兴奋性氨基酸受体表达的影响
- Author:
Wei-Bin WANG
;
Chun-Feng SONG
;
Pei-Yuan LV
;
Yu YIN
;
Cuiping LIANG
;
Jingfeng FAN
;
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion;
N-methyl-D-aspartate receptor;
action
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Hydergine on expression of N-methyl-D-aspartate receptors in hippocampus and actions of mice with ischemia-reperfusion injury.Methods 36 mice were randomly divided into model group,Hydergine group and sham-operated group. The models of ischemia-reperfusion injury were made by knotting bilateral common carotid arteries. The behavioral abnormalities were investigated by step-down test and water maze test, and the expressions of N-methyl-D-aspartate receptors in neurons of hippocampus were observed by immunohistochemistry technique. Results Compared with model group, the performance records of learning and memory in Hydergine group were better (all P
