Cognitive Ability and Apolipoprotein E Genotypes in Long Lived Elderly in Bama area of Guangxi
- VernacularTitle:广西巴马地区长寿老人 ApoE 基因多态性与认知功能的关系
- Author:
Cai-You HU
;
Ze YANG
;
Chen-Guang ZHENG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
cognitive function;
cross-sectional study;
longevity;
gene associated
- From:
Chinese Mental Health Journal
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relation between the distribution ofapolipoprotein E(apoE)genotypes and cognitive impairment onset in long lived elderly in Bama area in Guangxi in china.Methods:A total of 112 long lived elderly aged 90 years old and over were collected and tested with MMSE to inspect their cognitive function,and they were classified into cognition impaired group and non-impaired group according to MMSE scores.We determined the AopE genotypes by way of PCR-RFLP technique,and compared the differences of AopE allele and genotype of the two groups.Result:The cognitive disfunction was found to be 14.29% in long lived elderly in Bama area.The ApoE ? 3/? 3 genotypes have highest frequency in long-lived elderly,next is ?2/3,and ?4/4 is lowest frequency.There were significant differences of ? 4 allele frequencies between cognition impaired group and non-impaired group(P
