Cognitive Function and P300 Potentials in First-Episode Schizophrenia Treated with Quetiapine and Risperidone
- VernacularTitle:奎硫平、利培酮对首发精神分裂症患者认知功能及P300的影响
- Author:
Chang-Hong WANG
;
Yan LI
;
Xu LIU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
psychiatry;
schizophrenia;
case-control study;
cognition;
P_(300) potentials;
Quetiapine Risperidone
- From:
Chinese Mental Health Journal
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of quetiapine and risperidone on cognitive function of first-episode schizophrenic patients.Methods:A randomized comparative clinical design was applied to compare the cognitive function of 67 patients with first-episode schizophrenia treated with quetiapine(n=35,25-750mg/d)and risperidone(n=32,1-7rag/d)before and after 12-week treatment.PANSS,WMS and P300 were used to evaluate adverse effects of drags and cognitive function.Results:The Long-term memory,Short-term memory,Immediate memory,Memory Quotient of first-episode schizophrenia were damaged obviously.Latency periods of P_2、N_2 and P_3 of P_(300) potentials with first-episode schizophrenia group were longer than the control group,The amplitudes of P_2 and P_3 of P_(300) potentials with first-episode schizophrenia group were lower than the control group(P
