Abnormally activation of lymphocyte by auto-platelet with idiopathic throm bocytopenic purpura
- VernacularTitle:特发性血小板减少性紫癜患者血小板对自身淋巴细胞的异常激活
- Author:
Yanhong LIU
;
Chunxia WANG
;
- Publication Type:Journal Article
- Keywords:
Purpura,thrombocytopenic,idiopathic;
HLA-DR antigens
- From:
Chinese Journal of Laboratory Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HLA DR on the platelet membrane and the activation of CD4 +T lymphocyte with idiopathic thrombocytopenic purpura (ITP) Methods By flow cytometry, HLA DR expressed on platelet membrane and IL 2 level produced by activated CD4 +T lymphocyte in 60 patients with ITP and 60 normal volunteers were measured Results The percentage of platelet expressing HLA DR (0 808?0 218)% measured in 60 patients with ITP by flow cytometry analysis was markedly higher than that in control subjects (0 025?0 019)% ( P
