Clinical significance of ADAMTS13 activity in thrombotic thrombocytopenic purpura patients
- VernacularTitle:血栓性血小板减少性紫癜患者血浆VW因子裂解蛋白酶活性测定的临床意义
- Author:
Xue-Wen WANG
;
- Publication Type:Journal Article
- Keywords:
Thrombotic thrombocytopenia purpura;
ADAMTS13;
Clinical significance
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
A deficient of plasma VW factor-cleaving protease (ADAMTS13) and appearance of unusually large multimers induced platelets aggregation in capillaries and arterioles. It was critical pathogenesis of thrombotic thrombocytopenia purpura (TTP). ADAMTS13 activity has been measured over 1000patients of TTP and hemolysis uremia syndrome (HUS) since 1997. Diagnostic sensitivity and specificity,as well as clinical significance of ADAMTS13 deficiency for TTP patients were evaluated,and synthetical diagnosis basis of TTP were raised.
