structure and functions of Collagen ⅩⅧ/endostatin
- VernacularTitle:胶原ⅩⅧ/内皮抑素的结构和功能
- Author:
Xiaodong YANG
;
Zhe XU
;
Fukun LIU
;
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
Endostatin;
Collagen ⅩⅧ;
Neovascularization;
Neoplasm
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
The angiogenesis inhibitor endostatin is a 20 000 C terminal fragment of collagen ⅩⅧ.Endostatin inhibits endothelial cell migration in vitro and appears to be highly effective in murine in vivo studies. Endostatin is a specific and the most effective antiangiogenisis till now. The molecular mechanisms behind the inhibition of angiogenesis have not yet been elucidated.The structure and functional roles in angiogenesis of wllagen ⅩⅧ/endostatin were reviewed.
