Study of correlation between polymorphism of HLA-DRB allele and susceptivity of atopic dermatitis
- VernacularTitle:人白细胞抗原-DRB基因多态性与特应性皮炎易感性的相关性研究
- Author:
Hongli ZHAO
;
Xueqian WANG
;
Yuhuan ZHANG
;
Xiaohui SUN
;
- Publication Type:Journal Article
- Keywords:
Atopic Dermetitis;
Human Leucocyte Antigen;
Single-Strand Conformation Polymorphism
- From:
Chinese Journal of Laboratory Medicine
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To look for susceptible and resistant HLA gene of Atopic Dermatitis(AD), analyze single strand conformation polymorphism of the susceptible gene and observe whether the base sequence was different from healthy Method Polymerase chain reaction sequence specific primer(PCR SSP)was used to classify the HLA DRB allele of 122 patients and 80 controls PCR single strand conformation polymorphism(SSCP) was used to analyse the susceptible gene Results The DR 3 frequency of extrinic type of “pure” AD(EAD)group and complicated group was higher than that of the control group ( RR =5 27 and 3 59 respectively P 0 05). Conclusion HLA DR 3 was the susceptible gene of AD, while HLA DR 6 was the resistant gene of AD It indicated that people with HLA DR 3 were reliable to AD, while people with HLA DR 6 were not But there was no base difference between these people and the healthy in HLA DR 3
