Research on the antitumor actions of extracts from the fruiting body of coriolus versicolor
- VernacularTitle:云芝子实体提取物的抗肿瘤作用研究
- Author:
Rui LIU
;
Yayi HOU
;
Weiyun ZHANG
;
Xiaodong HAN
;
- Publication Type:Journal Article
- Keywords:
CVE;
Antitumor;
IgG;
Proliferation of lymphocytes;
P53 protein;
VEGF protein
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antitumor actions of polysaccharide extracts from the fruiting body of coriolus versicolor (CVE). Methods:Hepatoma HepA cells were injected into mice subcutaneously. Different doses of CVE were given by gavage. On the 7 th and 14 th day, tumor inhibitive rates were calculated. ELISA was performed to measure the serum IgG level; MTT was used to examine CVE′s effects on the proliferation of T lymphocytes of thymus. Immunohistochemistry was used to determine CVE′s influence on the expression of tumor related genes P53 and VEGF in liver. Results: CVE may evidently inhibit the growth of the transplanted HepA tumors. Its effects on the serum IgG level and on the proliferation of T lymphocytes of thymus were also significantly. Also, CVE markedly decreased the expression of P53, VEGF genes in liver. Conclustion: CVE had significant antitumor effects in vivo . The mechanisms may involve immune modulation effects and antimetastasis actions.
