Application of microsurgery in fabrication of vascularized engineered tissue
- VernacularTitle:显微外科与血管化组织工程组织的构建
- Author:
Guoxian PEI
;
Kuanhai WEI
;
- Publication Type:Journal Article
- Keywords:
Microsurgery;
Tissue engineering;
Vascularization
- From:
Chinese Journal of Orthopaedic Trauma
2002;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Vascularization is the basis of tissue regeneration. To get engineered tissue, it is necessary that timely and enough nutrition be available to the seed cells, especially those within the biomaterials. Therefore reconstruction of blood supply is the key step leading from basic research to clinical application. Thee major methods have been used to reconstruct blood supply: promotion of vessel growth by means of VEGF, combined grafting of vascular endothelial cells and osteoblasts and microsurgical techniques. The microsurgical techniques, such as wrapping around with pedicled fascia flap, wrapping around with vascularized muscle flap and blood vessel implanting, can help reconstruct blood supply when engineered tissue is fabricated. When engineered tissue is used in clinic to repair defects in vicinity, vascularization can be done in the defect area. But when no fascia flap, muscle flap or vessel can be used in the defect area, the local defects can be repaired through reconstruction of vascularized engineered tissue in other areas and through second stage transplantation with microsurgical techniques.
