Homeostasis between survival and apoptosis of Schwann cells after injury of peripheral nerve
- VernacularTitle:周围神经损伤后雪旺细胞生存与凋亡的动态平衡
- Author:
Jiyin HE
;
Jie LAO
;
- Publication Type:Journal Article
- Keywords:
Schwann Cells;
NGF;
P75;
Apoptosis;
Nerve regeneration
- From:
Chinese Journal of Orthopaedic Trauma
2002;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Schwann cells proliferate and the axis cylinder regenerates after the injury of the peripheral nerves. Schwann cells are a vital factor in the process of regeneration of injured nerves. The article summarizes the survival and apoptosis adaptation of Schwann cells after the injury of the peripheral nerves. It discusses massive NGF secreting, P75 expressing, and IGF 2, PDGF BB, NT 3 and CNTF secreting. It also supposes that there might be a homeostasis between survival and apoptosis in the proliferated Schwann cells and brings forward the question regarding reassessment of administration of NGF to enhance regeneration of the injured peripheral nerves.
