The experimental study on the animal model of guinea-pig chronic heart failure and compensatory hypertropgy
- VernacularTitle:豚鼠慢性充血性心力衰竭及致心肌肥厚模型的研究
- Author:
Xiaojing ZHAO
;
Changzong CUI
;
Haizhu ZHANG
;
Jian LIU
;
Kexin DU
;
- Publication Type:Journal Article
- Keywords:
Guinea pigs;
Ascending aorta;
Chronic heart failure;
Hypertrophy
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the animal model of guinea pig chronic heart failure and compensatory hypertrophy. Methods:Thirteen chronic heart failure models were made by placing a constricting band around the ascending aorta of guinea pigs,raised in the same house of 10 normal guinea pigs. The contrasting indexes in 6 weeks include: clinical features, hemodynamics, the mass ratio of ventricular over body, the width of left ventriculat hypertrophy. Results:One model died, 4 models without dyspnea showed increasing in left ventricular pressure and the mass ratio of ventricular over body, whereas the left ventricular end diastolic pressure showecl no significant different. Eight models with dyspnea showed striking increasing in left ventricular pressure and left ventricular end diastolic pressure, as well as the mass ratio of ventricular over body and the width of left ventricular hypertrophy. Conclusion:The animal model of guinea pig chronic heart failure and compensatory hypertrophy may be formed by constricting the ascending aortas of guinea pigs for 6 weeks.
