Vasodilation effects and mechanism of 17 ?-estradiol on rat thoracic aortas
- VernacularTitle:17-?雌二醇对大鼠胸主动脉的舒张作用及其机制的研究
- Author:
Gengze WEI
;
Yunlong ZHU
;
Jun YU
;
Shuxin LIN
;
Yunfan KANG
;
Rong WANG
;
- Publication Type:Journal Article
- Keywords:
estradiol;
Theoracic aorta;
K Ca;
K ATP;
NO;
cGMP
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the vasodilatative roles and mechanisms of 17 ? estradiol(E 2) on rat thoracic aortas (TA). Methods:Rings cut from thoracic aortas of female rats were used by in vitro perfusion. The endothelium dependent and endothelium independent vasorelaxing effects of E 2 were measured. Furthermore, it was also observed whether the relaxing effects of E 2 were modulated by tamoxifen, N ? nitro L arginine methyl ester(L NAME),TEA, methylene blue(MB) or Methylene Blue(MB).Results:E 2 caused acute concentration dependent relaxation in TA with endothelium, but not significant without endothelium( P
