Expression of adhesion molecules in polymyositis
- VernacularTitle:粘附分子在多发性肌炎中的表达
- Author:
Wentao WU
;
Weisong QIN
;
Fuyuan SHAO
;
Guanghui CHEN
;
Xinfeng LIU
;
- Publication Type:Journal Article
- Keywords:
Polymyositis;
Adhesion molecules;
Two colour immunofluoresence
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the role of adhesion molecules in the pathogenesis of polymyositis. Methods:The abnormal expression of adhesion molecules on T cells in peripheral blood and muscle fibers from patients with myositis was analyzed by two colour immunofluoresence and RT PCR methods respectively. Results:The expression of adhesion molecules including lymphocyte function associated antigen 1(LFA 1 ),very late antigen 4(VLA 4) on T cells in peripheral blood and intercellular adhesion molecule l(ICAM 1) on muscle fibers from patients with myositis was markedly higher than that in the healthy control group. Conclusion: These findings suggested that adhesion molecules may be responsible for the migration of T cells and destraction of muscle fibers.
