The expression of adhesion molecules on sciati c nerve of STZ-induced diabetic rats and the effect of cilostazol treatment
- VernacularTitle:糖尿病大鼠坐骨神经病变与细胞黏附分子-1和P-选择素变化的相关性及西洛他唑的治疗作用
- Author:
Zhe WANG
;
Jiajun ZHAO
;
Ling GAO
;
- Publication Type:Journal Article
- Keywords:
Adhesion;
Sciatic nerve;
Diabetes neuropat hy;
Cilostazol
- From:
Chinese Journal of Diabetes
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression of adhesion mol ecules (CD 54 、CD 62p ) on diabetic neuropathy in the STZ induced rats and the effect of cilostazol treatment.MethodsSD rats were divided into four groups: normal control, diabetes control, insulin and cilostaz ol treated group. Sciatic nerve conductive velocity, the level of CD 54 /CD 62p on the surface of mononuclear cell/platelet were examined, and ultrast ructure of sciatic nerve was observed.ResultsCilostazol incr eased sciatic nerve conductive velocity significantly [DM=(20.3?2.2) m/s vs ci lostazol=(28.9?7.9)m/s,(P
