The Effects of EGb and Venlafaxine on the Expression of nNOS and NO level in Rats of Depression Model
- VernacularTitle:银杏叶提取物联合盐酸文拉法辛对抑郁大鼠海马nNOS蛋白表达及NO水平的影响
- Author:
Xiaosong QIN
;
Kuihe JIN
;
Baokun DING
;
- Publication Type:Journal Article
- Keywords:
psychiatry stress animal studies depression extract of Ginkgo biloba neuron nitric oxide synthase rats
- From:
Chinese Mental Health Journal
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the changes of hippocampus in the rats of depression model and study the protective effects of EGb (extracts of gingkobiloba) and Venlafaxine on brain injury. Methods: Rats were divided into 6 groups. Groups A served as normal control. Group B?C?D?E?F received 21 days chronic stress. Group C?D?E?F were fed with normal food, EGb, Venlafaxine and EGb+Venlafaxine respectively for 28 days after enduring 21 days chronic stress. Every rat had been observed open-field behavior before decapitated.One side of the hippocampus were measured the expression of nNOS by immunohistochemistry method, the other side hippocampus and the serum were measured the concentrations of NO.Results:The expression of protein nNOS in hippocampus of group B was increased compared with group A (P
