The study on angiotensin converting enzyme and angiotensin type 1 receptor gene polymorphism in patients with vertebro-basilar insufficiency
- VernacularTitle:椎基底动脉供血不足患者与血管紧张素转换酶基因和AT_1R基因多态性的相关性研究
- Author:
Hongfen LI
;
Zhixia SHEN
;
Zihong LIU
;
Xiaodong YUAN
;
Shouling WU
;
- Publication Type:Journal Article
- Keywords:
Vertebro basilar insufficiency;
Peptidyl dipeptidase A;
Receptors, angiotensin;
Polymorphism, single nucleotide
- From:
Chinese Journal of Laboratory Medicine
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Investigate the relationship between an in sertion (I)/deletion (D) polymorphism for angiotensin converting enzyme (ACE) and A(1166)C Polymorphism of angiotensin type 1 receptor(AT 1R) genes in patients with vertebro basilar insufficiency(VBI). Methods In this study, We examined 120 patients with VBI and 146 normal controls. The genotype for I/D of ACE and A(1166)C of AT 1R was assessed using polymerase chain reaction (PCR) and refrained fragment length polymorphism(RFLP), respectively. Then we compared the genotype frequency distribution among subjects.Results As a whole, there was significant difference in the distribution of ACE (I/I, I/D and D/D) and AT 1R (A/A and A/C), respectively. D allele frequency was higher in patients compared with the normal controls. Our study also revealed that Ⅱ AA and DD AA genotype frequency in VBI was higher than that in the normal controls.Conclusion The D allele for ACE and C(1166) allele of AT 1R may correlated with VBI.Ⅱ genotype for ACE and AA genotype had a positive con influence on the VBI. The affection of DD AA genotype on VBI was negative.
