The detection of FLT3/ITD gene mutation in Acute nonlymphoblas tic leukemia patients by use of polymerase chain reaction and its clinical significance
- VernacularTitle:聚合酶链反应检测急性非淋巴细胞白血病患者FLT3/ITD基因突变及临床意义
- Author:
Bing XU
;
Yan ZHANG
;
Hong TIAN
;
Shuyun ZHOU
;
- Publication Type:Journal Article
- Keywords:
Leukemia, nonlymphocytic, acute;
Gene
- From:
Chinese Journal of Laboratory Medicine
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To study the FLT3 gene expression and its internal tandem duplication(ITD) mutation in acute nonlymphoblastic leukemia(ANLL) patients.Method Polymerase chain reaction was used to detect the FLT3/ITD mutation in 71 ANLL patients.Results The expression of FLT3 gene were detected in 65/71(91 5%) ANLL cases and ITD mutation was found in 17 cases. 23 9% of ANLL cases were found with FLT3/ITD mutation. The leucocyte count and the percentage of bone marrow blast cells were higher in ANLL patient with FLT3/ITD mutation than that in the ANLL patient without FLT3/ITD mutation (P
