ANALYSIS OF L-VALINE BIOSYNTHESIS MECHANISM BY METABOLIC FLUX BALANCE MODEL
- VernacularTitle:L-缬氨酸生物合成中的代谢流量分析
- Author:
Ke-Xu ZHANG
;
Li-Li ZHAO
;
Bei ZHANG
;
Ning CHEN
;
- Publication Type:Journal Article
- Keywords:
L-valine, The metabolic flux distribution, Metabolic flux analysis, Linear prog ram$$$$
- From:
Microbiology
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Using metabolic flux balance model , the metabolic flux balance of L- v aline synthesis was established in this paper by material balances and linear p rogramming method. The analysis results indicate that 62.8% metabolic flux ent er ed EMP pathway and 38.2% metabolic flux entered the HMP pathway. And only 9.2 % c arbon entered the TCA cycle. But comparing to the optimal flux distributions of 92.31, the production of L-valine should be improved from the genetic manipula ti on and fermentation control through reducing byproduct of amino acid and decreas ing the metabolic flux.
