Effects of dantrium~ and nimodipine on heart function of rabbits after severely burns
- VernacularTitle:丹曲林和尼莫通对烧伤家兔心功能的影响
- Author:
Baojun YU
;
Zhiguo LIU
;
Zhaofan XIA
;
Jieshou LI
;
- Publication Type:Journal Article
- Keywords:
Heart function;
Dantrium ○R;
Nimodipine;
Burn
- From:
Journal of Medical Postgraduates
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To observe the effects of Dantrium and nimodipine on myocardial function in severely burned rabbits. Methods: Full thickness scald burn covering 30% TBSA was produced on rabbits. LVSP, ?dp/dt max ,BPs, BPd, BPm were recorded through a MPA Ⅳ Biological Signal Analysis System before and after burn constantly. All burn animals were resuscitated with lactate Ringer's solution according to the Parkland formula. Dantrium and nimodipine were administered respectively. Results: The myocardial contractility and relaxation were depressed after burn trauma, with a short phase of enhancement immediately after scalding. LVSP,?dp/dt max , BPs and BPm were increased after intravenous injection of Dantrium. The effect of nimodipine was not same as Dantrium. LVSP,?dp/dt max ,were enhanced after infusing nimodipine slowly. Conclusions: The rabbits myocardial function was depressed after severely burn. Dantrium and nimodipine could both improve the myocardial function. Dantrium ○R was suitable for treating the animal with burn shock and myocardial malfunction.
