Progress of diagnosis and management of disseminated intravascular coagulation
- VernacularTitle:弥散性血管内凝血的诊断与治疗进展
- Author:
Xuewen WANG
;
- Publication Type:Journal Article
- Keywords:
Disseminated intravascular coagulation;
Diagnosis;
Treatment
- From:
Journal of Medical Postgraduates
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin (IL) 1,IL 6,plasminogen activator inhibitors 1(PAI 1),tumor necrosis factor(TNF),endothelin, silectin E, tissue factor(TF) and platelet activating factor(PAF)etc. participated in pathological processes of disseminated intravascular coagulation(DIC).Diagnosis of DIC should possess:①procoagulant system activation,②fibrinolytic system activation,③inhibitor consumption,④cytokine release,⑤cellular activation, and ⑥resultant end organ damage. For an objective diagnosis of DIC,①,②,③,⑥must be present and documented by appropriate laboratory parameters. To remove the triggering process or the underlying disease during the treatment of DIC was fundamental. Anticoagulation therapy and component therapy were the foundation stone. The inhibitor of proteinase, thrombin, factor ?a,and drugs of enhancing anticoagulation or (and) fibrinolytic, ie, platelet activating factor (PAF),activating protein C (APC),recombinant thrombomodulin (rTM) etc. are effective drugs in studying and developing.
