The development about activation of protein kinase C and diabetic vascular complications
- VernacularTitle:蛋白激酶C激活与糖尿病血管并发症研究的新进展
- Author:
Hongliang LI
;
Yerong YU
;
- Publication Type:Journal Article
- Keywords:
Protein kinase C;
Insulin resistance;
Diabetic vascular complication
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Protein kinase C(PKC) is a serine/threonine kinase groups including a series of isoenzyme.Hyperglycemia and elevated free fatty acid can affect signal transduction pathway function,in particular activation of diacylglycerol (DG) and PKC,which occurs in the diabetic state. Activation of PKC lead to insulin resistance and diabetic vascular complications. PKC ? isoform selective inhibitor(LY 333531) and vitamin E have shown potential effect as therapies for diabetic vascular complication.
