Local biologic reactions induced by wear debris
- VernacularTitle:磨损微粒诱导的局部生物学反应
- Author:
Junhua WANG
;
Jianning ZHAO
;
Yurong WANG
;
Sujia WU
;
- Publication Type:Journal Article
- Keywords:
Total hip replacement;
Hip prostheses;
Wear debris
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aseptic loosening is the most common cause of implant failure after total hip replacement. Studies have shown that the aseptic loosening is related to the cellular mechanisms involved in the interactions between particulate wear debris from materials used in the prothesis and the surrounding macrophages. A fundamental understanding of how particulate debris incites the release of biologic mediators, such as the proinflammatory/proresorptive cytokines or cellular recruitment, will provide important information regarding the development of interventional therapies to prolong the life of a total hip replacement.
