The clinical significance of nuclear matrix protein 22 in the diagnosis of bladder transitional cell carcinoma
- VernacularTitle:尿NMP-22对诊断膀胱移行细胞癌的临床意义
- Author:
Jingping GE
;
Jianping GAO
;
Zhengyu ZHANG
;
Song XUE
;
Linfeng XU
;
Peihe LIANG
;
Ming QI
;
Hua XIONG
;
- Publication Type:Journal Article
- Keywords:
Bladder transitional cell carcinoma;
Neoplasm;
Diagnosis;
Nuclear matrix protein
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To evaluate the clinical significance of nuclear matrix protein 22 (NMP 22) in the detection of bladder transitional cell carcinoma (BTCC) and compare with voided urine cytology(VUC). Methods: A total of 69 cases with voided urine samples for NMP 22 and VUC test were included in this study. Thirty of them were BTCC patients(BTCC group) and twenty nine suffered from other urological diseases (nonbladder cancer group, NBC group). Ten were healthy volunteers (control group). Results: The NMP 22 values for BTCC group (67.3 U/ml) were significantly higher than that of NBC group(7.4 U/ml) and control group (4.3 U/ml)( P 0.05). NMP 22 was more sensitive than VUC in low grade BTCC(Ⅰ,Ⅱ)(62.50% vs 12.50%,P 0.05). Conclusions:Urinary NMP 22 is a useful marker for the early diagnosis of BTCC. It is more sensitive than VUC in low stage and grade BTCC.
