Expression and its significance of GAP-43 and TrkB mRNA in the rat hippocampus after epilepsy induced by pilocarpine
- VernacularTitle:匹罗卡品致癎大鼠海马GAP-43与TrkB基因表达及其意义
- Author:
Guoliang LI
;
Bo XIAO
;
Guangjie XIE
;
Bei ZHANG
;
Changqi LI
;
Xiaoqiong WU
;
- Publication Type:Journal Article
- Keywords:
Epilepsy Temporal lobe Pilocarpine Tyrosine kinase receptor B Growth-associated protein-43
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and its significance of growth-associated protein(GAP-43 ) and brain-derived neurotrophic factor (BDNK) receptor TrkB gene in rat hippocampus after epilepsy induced by pilocarpine (PILO). Methods In situ hybrid histochemical method was used to observe the changes of the expression of GAP-43 and TrkB mRNA in hippocampus after status epilepticus( SE) induced by PIOL. Results At 3 - 6h following the onset of status epilepticus(SE), TrkB mRNA expression was dramatically high than control groups in the dentate gyrus granule cell and CA3,CA1 pyramidal cell layers(P
