Serum paraoxonase and its relationship to atherosclerosis
- VernacularTitle:对氧磷酶与动脉粥样硬化的关系
- Author:
Chunni ZHANG
;
Li LI
;
Junjun WANG
;
- Publication Type:Journal Article
- Keywords:
Paraoxonase;
Antioxidation;
Activity;
Genetic polymorphisms;
Atherosclerosis
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Human serum paraoxonase (PON1) is a high density lipoprotein (HDL)associated enzyme capable of hydrolyzing lipid peroxides in vitro .PON1 has recently attracted attetion as a key factor against oxidative modification of LDL by involving in degradation of oxidized phospholipid and may therefore play an important role on the prevention of the atherosclerotic process of HDL.The concentration and activity of PON1 have been shown to be associated with the risk of atherosclerosis.In addition,the genetic polymorphisms of PON1 have been proposed as a genetic marker of risk for coronary artery disease.The measurement of the genetic polymorphisms of PON1 may be helpful in the prevention of coronary artery disease.
