The effect of matrix metalloproteinase-9 in acute lung injury following cardiopulmonary bypass
- VernacularTitle:基质金属蛋白酶-9在体外循环肺损伤中作用的初步研究
- Author:
Changtian WANG
;
Hua JING
;
Zhongdong LI
;
Xiaonan HU
;
Guohua DONG
;
Liguo LUO
;
Weidong GU
;
Yi SHEN
;
Biao XU
;
Jianjun QIAN
;
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Matrix metalloproteinase 9;
Lung injury
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To study the correlation between plasma matrix metalloproteinase 9(MMP 9) concentration and acute lung injury following cardiopulmonary bypass(CPB). Methods: Human plasma was obtained after informed consent from twenty patients undergoing CPB. Plasma was collected at the beginning of CPB, 5 minutes after the initiation of CPB, at the termination of CPB, 1 hour after the termination of CPB and 6 hours after the termination of CPB. All samples were analyzed by standard enzyme linked immunosorbent assay (ELISA). A aDO 2 and respiratory index (RI) was measured at the termination, 1 hour and 6 hours after termination of CPB. The cross clamp times, CPB times and the time to extubation was recorded. Data were expressed as means ?SE and assessed by analysis of variance (ANOVA).The regression analysis was utilized to define the correlations of variables measured( A aDO 2 ,RI, cross clamp times, CPB times and the time to extubation ) at the end of CPB. Results: Plasma MMP 9 concentration was significantly increased at the end of CPB (430.6?50)?g/L( P
