MUTAGENICITY OF STREPTOMYCES REGENSIS PRODUCING A NOVEL ANTIBIOTICS AGPM
- VernacularTitle:新型抗生素AGPM产生菌藤黄灰链霉菌的诱变育种
- Author:
Jianyong ZHANG
;
Jinyang NIU
;
Guibin CHEN
;
Yingjin YUAN
;
Zong HU
;
- Publication Type:Journal Article
- Keywords:
Streptomyces regensis , Antitumor antibiotics, UV irradiation, Synergism
- From:
Microbiology
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
of Streptomyces regensis was isolated from soil to produce a novel antibiotic AGPM of a strong biological activity of antitumor The strain was irradiated by UV after treatment with LiCl to give a AGPM yield of 1 87?10 2 mg mL 1 , 2 2 times higher than that of the original strain The optimum UV irradiation time was 30～60 s and the best LiCl concentration was 0 05～0 09 mol/L The fermentation of AGPM was conducted in a 30 L stirred tank, the maximum yield of AGPM using the mutants reached 1 85?10 2 mg mL 1 , while that using the original strain was only 0 85?10 2 mg mL 1
