STUDY ON THE MICROORGANISM FERMENTATION OF ADENOSINE WITH MUTATIVE STRAINS OF LACK OF OR PRODUCING SOME IMPORTANT ENZYMES IN NUCLEIC ACID METABOLISM
- VernacularTitle:肌苷菌核酸代谢关键酶缺失和形成选育腺苷菌的研究
- Author:
Jianxin BAI
;
Xiaohong ZHU
;
Yiping ZHANG
;
Honglian WANG
;
Chong DENG
;
- Publication Type:Journal Article
- Keywords:
Adenosine, Xanthine, AMP deaminase, GMP reducase, IMP dehydrogenase
- From:
Microbiology
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
According to the theory of nucleic acid metabolism, the different select models were designed By means of physical and chemical derived to the production of inosine Bacillus Subtilis JSIM 1019, we have got the mutative strains of auxotroph of different component, the mutative strains lacking of relating enzyme, the mutative strains resisting some metabolic analog in turn Restrain of the production to metabolite has been relieved Two mutative strains of auxotroph xanthine, X 13 and so on were obtained And it also has resistance to 8 azaguanine After the mutative strains had been separated into the single srain respectively, we got X 13 4 the maximum accumulation of adenosine reachs 12 43g/L in substratum cultivated for 72 hours at 36℃
